# TRD 2: Metabolic Markers

> **NIH NIH P41** · HUGO W. MOSER RES INST KENNEDY KRIEGER · 2024 · $197,381

## Abstract

TRD 2: Metabolic Markers
Lead Principal investigator: Richard Edden, Professor of Radiology
Co-investigators: Peter van Zijl, Peter Barker, Georg Oeltzschner, Jiadi Xu, Hye-Young Heo,
Nirbhay Yadav.
This TRD will develop biomarkers of brain metabolism, using magnetic resonance spectroscopy
(MRS) and chemical exchange-saturation transfer imaging (CEST-MRI). We will develop new
editing schedules for multiplexed editing MRS, allowing the simultaneous resolution of several
low-concentration metabolites of interest to collaborative projects, including neurotransmitters
such as GABA, antioxidants such as glutathione, and neuromodulators such as N-
acetylaspartylglutamate. We will combine these methods with spectroscopic imaging readouts
and develop multi-spectrum linear combination modeling approached for quantification. Edited
CEST approaches, tuning acquisition parameters to improve specificity of detection, CEST
fingerprinting, and single-shot z-spectrum approaches will be developed. Deep learning tools
for the analysis of these data will also be developed, with a particular focus on the integration
of methods, and spectral resolution enhancement and metabolic editing by MRSI-based
training of CEST analyses. Acquisition and analysis tools developed under this TRD will be
disseminated to collaborative projects and service projects, to establish reproducibility in a new
setting, and to the broader community.

## Key facts

- **NIH application ID:** 10828784
- **Project number:** 5P41EB031771-04
- **Recipient organization:** HUGO W. MOSER RES INST KENNEDY KRIEGER
- **Principal Investigator:** Richard Anthony Edward Edden
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $197,381
- **Award type:** 5
- **Project period:** 2021-07-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10828784

## Citation

> US National Institutes of Health, RePORTER application 10828784, TRD 2: Metabolic Markers (5P41EB031771-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10828784. Licensed CC0.

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