# Development of Strategies for the Synthesis of Heterocycles

> **NIH NIH R35** · UNIVERSITY OF FLORIDA · 2024 · $358,483

## Abstract

Project Summary/Abstract
Heterocycles are ubiquitous components of pharmaceutical drugs essential for human
health. A particularly attractive approach to nitrogen containing heterocycles is the
modification of cheap and readily available amines via C–H bond functionalization.
However, methods that efficiently accomplish this task typically require the use of
expensive transition metal catalysts and/or oxidants. This proposal is focused on the
design and development of efficient and practical methods for amine functionalization,
including the development of asymmetric variants. The main goal is the alpha-
functionalization of amines through conceptually new and underdeveloped methods of
substrate activation. Unique methods for the synthesis of heterocycles will also be
explored in the context of asymmetric Lewis and BrØnsted acid catalysis. In addition to
targeting the rapid preparation of compounds related to structures with known biological
activities, efforts will center on the development of particularly powerful reactions that
rapidly produce new polycyclic heterocycles. A priority is the generation of new
structural frameworks that are absent from current drug discovery screening libraries.

## Key facts

- **NIH application ID:** 10828808
- **Project number:** 5R35GM149246-02
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Daniel Seidel
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $358,483
- **Award type:** 5
- **Project period:** 2023-05-01 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10828808

## Citation

> US National Institutes of Health, RePORTER application 10828808, Development of Strategies for the Synthesis of Heterocycles (5R35GM149246-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10828808. Licensed CC0.

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