# Genetics of Cardiovascular Disease in Chronic Kidney Disease

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $446,845

## Abstract

ABSTRACT
Cardiovascular disease is a main cause of death and disability in individuals with chronic kidney disease (CKD)
but little is known on the genetic factors accounting for the increased cardiovascular disease burden in CKD.
Genome-wide association studies have identified several loci for cardiovascular disease and subclinical
atherosclerosis traits. Studies have also shown that genetic variants that regulate gene expression have
important roles in complex traits. We propose to test regulatory regions of the genome associated with
cardiovascular outcomes using approaches that integrate gene expression data to genome-wide genotypes.
We will use the comprehensive clinical and biomarker data from the Chronic Renal Insufficiency Cohort
(CRIC), a multi-ethnic and longitudinal study of individuals with CKD. CRIC has adjudicated cardiovascular
events in all participants and the study has already documented a high burden of atherosclerosis and
cardiovascular disease in CKD. We will perform genome-wide association studies of cardiovascular outcomes
using dense imputed genotypes from multi-ethnic reference panels obtained from the Trans-Omics for
Precision Medicine (TOPMed) Program to identify new loci in individuals with CKD (Aim 1). To identify putative
causal genes associated with cardiovascular disease in CKD, we will use predicted gene expression
approaches and expression quantitative trait loci from ancestry-matched datasets (Aim 2) and multi-tissues
(Aim 3). This project uses innovative concepts and approaches by integrating transcripts and genotypes for
gene discovery in a high-risk population for cardiovascular disease. This project aligns with NHLBI mission to
reduce the burden of CVD.

## Key facts

- **NIH application ID:** 10829441
- **Project number:** 5R01HL163972-03
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Nora Franceschini
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $446,845
- **Award type:** 5
- **Project period:** 2022-05-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10829441

## Citation

> US National Institutes of Health, RePORTER application 10829441, Genetics of Cardiovascular Disease in Chronic Kidney Disease (5R01HL163972-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10829441. Licensed CC0.

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