# NAMPT regulation of fracture tissue metabolism during bone healing

> **NIH VA I21** · VA LOMA LINDA HEALTHCARE SYSTEM · 2024 · —

## Abstract

This proposal will optimize NAD functions in the metabolism of fracture tissues for the enhancement of
bone fracture repair in an obesity/Type-2 diabetic condition, a condition that is common in the general
population and even more frequent among veterans. It is well established that Type-2 diabetics suffer from
impaired bone healing caused by an insufficient metabolic response to the requirements of tissue repair. In
this study, an obesity/Type-2 diabetes condition will be induced in mice and the redox potential of local
tissues improved through the augmentation of NAMPT functions in the fracture tissues. Selected agonists of
NAMPT will be screened for their effects in periosteal cells, therapeutic candidates locally applied to the
fracture tissues in obesity/Type-2 diabetic mice and fracture healing evaluated. The completion of the
proposed studies should facilitate the development of novel therapeutic interventions that improve tissue
responses to the metabolic requirements of wound repair.

## Key facts

- **NIH application ID:** 10830307
- **Project number:** 5I21RX004395-02
- **Recipient organization:** VA LOMA LINDA HEALTHCARE SYSTEM
- **Principal Investigator:** Charles Rundle
- **Activity code:** I21 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2024
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2023-05-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10830307

## Citation

> US National Institutes of Health, RePORTER application 10830307, NAMPT regulation of fracture tissue metabolism during bone healing (5I21RX004395-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10830307. Licensed CC0.

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