# Seasonal Conjunctivitis Outbreak Reporting for Prevention and Improved Outcomes (SCORPIO)

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $404,861

## Abstract

PROJECT SUMMARY/ABSTRACT
Seasonal and epidemic conjunctivitis (pink eye) infections are highly contagious and impose significant
economic burden in the United States and worldwide. Long-term visual impairment can occur. In children,
conjunctivitis may herald more serious systemic complications leading to hospitalizations and even deaths.
Current challenges to effective mechanisms to curtail outbreaks are the lack of tracking and reporting, poor
access to sample collection for analysis, limited diagnostic testing capabilities, and an incomplete
understanding of the pathogens involved. The overall goal of this project is to combine international
collaboration efforts and advances in genomic technologies to identify pathogens, global trends, pathogen
evolution, and the immune responses involved in the epidemiology of conjunctivitis. We propose to enhance
the understanding of the pathogenesis of conjunctivitis with the following aims. The first aim will determine how
adenovirus genome types vary within a region and across regions. The second aim will identify emerging
causes of seasonal and epidemic conjunctivitis. Finally, we will identify the local immune response signatures
of children and adults with infectious conjunctivitis. We expect that conjunctival gene expression profiles will
accurately predict disease associated complications. This project has the potential to improve public health
surveillance, guide targeted interventions, improve vaccine development, and elevate existing diagnostic
paradigms for conjunctivitis, to reduce both the financial and ocular health burden worldwide.

## Key facts

- **NIH application ID:** 10830372
- **Project number:** 5R01EY032041-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Thuy A Doan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $404,861
- **Award type:** 5
- **Project period:** 2021-03-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10830372

## Citation

> US National Institutes of Health, RePORTER application 10830372, Seasonal Conjunctivitis Outbreak Reporting for Prevention and Improved Outcomes (SCORPIO) (5R01EY032041-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10830372. Licensed CC0.

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