# Identification and Characterization of Microbial Metabolites in Immunity

> **NIH NIH R01** · BROAD INSTITUTE, INC. · 2024 · $786,407

## Abstract

PROJECT SUMMARY
The human microbiome is a key regulator of host immune function, and growing consensus suggests this
relationship is likely mediated by host interactions with microbial derived small molecules (i.e., metabolites).
Accordingly, microbial derived metabolites have been associated with numerous autoimmune, allergic, and
infectious diseases. However, the host-microbiome circuits that form the molecular basis of these associations
have not been fully characterized, and many microbial derived metabolites have not even been formally
identified. In this proposal, we describe a strategy to identify and functionally characterize microbial derived
metabolites isolated from patients in health and autoimmunity. Our collaborative team will isolate and
characterize novel metabolites from the human microbiome, map these associations to human immune
pathways, and identify the specific host receptors that engage microbial derived metabolites. This proposal will
establish causal relationships between microbial metabolites and human immune system function.

## Key facts

- **NIH application ID:** 10830383
- **Project number:** 5R01AI172147-03
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** Daniel Bartholomew Graham
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $786,407
- **Award type:** 5
- **Project period:** 2022-05-26 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10830383

## Citation

> US National Institutes of Health, RePORTER application 10830383, Identification and Characterization of Microbial Metabolites in Immunity (5R01AI172147-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10830383. Licensed CC0.

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