# Clinical Research Support Core

> **NIH NIH U2C** · HARVARD MEDICAL SCHOOL · 2024 · $1,838,022

## Abstract

PROJECT SUMMARY
The clinical and biomedical research culture established in the Undiagnosed Diseases Network (UDN) and the
Undiagnosed Diseases Program (UDP) led to collaborations within and across institutions that advanced
diagnostic success and biological understandings. In order to provide access to this process for a broader
number of patients, the individualized translational research process developed in the UDN and UDP must be
scaled. The overarching goal of the Clinical Research Support Core of the Data Management Coordinating
Center (DMCC) for Diagnostic Centers of Excellence (DCoEs) is to expand this model. This will be
accomplished through implementation of computational models that predict likelihood of diagnosis, integration
with national and international matchmaking networks, and expanding membership in the undiagnosed and
rare disease ecosystem to include previously under- and unrepresented entities. To achieve this goal, the
Clinical Research Support Core will focus on the following three specific aims: 1) Establish and manage Case
Review Committee meetings and accelerate applicant evaluations, 2) Accelerate diagnostic success by
expanding access of DCoE and UDP investigators and clinicians to expert consultants in other matchmaking
networks unlimited by geography or institution and by automating and standardizing case status updates, and
3) Provide subawards to DCoEs and/or their collaborators to facilitate on-site coordination, data sharing, and
pilot research projects and document progress toward overall DMCC goals.

## Key facts

- **NIH application ID:** 10830469
- **Project number:** 5U2CNS132415-02
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **Principal Investigator:** Francis Sessions Cole
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,838,022
- **Award type:** 5
- **Project period:** 2023-04-19 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10830469

## Citation

> US National Institutes of Health, RePORTER application 10830469, Clinical Research Support Core (5U2CNS132415-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10830469. Licensed CC0.

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