Data Science Facility Core ABSTRACT The vision for the Texas A&M Center for Environmental Health Research (TiCER) is to nucleate research and translational activities of faculty around the overarching theme “Innovative solutions for addressing exposure-stressor interactions in underserved population in urban and urbanizing areas in the state of Texas.” The Data Science Facility Core (DSFC) will provide key enabling services in data collection, storage, analysis, and integration to assist members of the Center to fulfill this mission. Key data science challenges that the DSFC will address include the high dimensionality of novel biological and chemical data streams, the need to translate data into actionable knowledge for environmental health decision-making, the need to geospatially contextualize data at the level of local communities. The DSFC will support these needs by leveraging data science expertise and resources across Texas A&M. There is a nearly ubiquitous need for such services across the Center’s four research themes: Stressors to Responses; Environment and Metabolism; Climate Change and Health; and Environmental Justice and Policy. Thus, the DSFC will serve as a key facilitator of interactions across the entire Center. The DSFC’s overarching goals are to provide novel and state-of-the-art data science services to support and integrate the Center’s scientific and outreach activities. This goal will be accomplished by providing services in several specialized and complex areas of data science— bioinformatics/biostatistics, risk sciences, and geospatial sciences—as well as providing a central data repository for Center investigators. In the bioinformatics/biostatistics area, the DSFC will focus on analysis and interpretation of complex data streams, especially the emergence of single cell-based analyses. In the risk assessment area, the focus will be on characterizing and predicting chemical toxicity through both mechanistic and data-driven mathematical/statistical models that integrate multiple diverse data sets. Furthermore, geographic information systems have emerged as an essential element of identifying and solving environmental health problems, especially climate change, as well as communicating and tailoring policy interventions. DSFC is adding personnel with extensive experience in geospatial analytics, data integration, and visualization, enabling it to substantially enhance the impact of Center research in support of communities and decision-makers. Finally, integration of data will be facilitated through a common data repository, the design and development of which will be closely coordinated with the rest of the Center, and which be indexed for searching and data mining. The DSFC will provide these services through direct support from Core senior personnel and as well as a flexible staff that can vary in effort depending on needs. The DSFC will work closely with the Administrative Core to encourage investigators’ use of the D...