Abstract This is a renewal application of the SMART MIND (Summer Mentoring and Research in Transdisciplinary Methodologies in the Neuroscience of Drug-Abuse) Program conducted at the University of Texas at El Paso (UTEP). Over the past 10 years of funding, we have provided an intensive training experience for 79 undergraduates, 18 high school teachers, and 8 high school students from underrepresented groups in science. Our overarching goal is to provide quality and effective summer experiences for diverse trainees to increase knowledge and skills in substance use disorders (SUDs). The program will utilize a transdisciplinary approach, involving training from a 13-member Interdisciplinary Faculty Team (IFT) on state-of-the-art behavioral and molecular bench science, community-based and health disparities research to address the multifaceted impact of SUDs on the brain and behavior. Each research cohort will consist of 12 undergraduate students, 6 of which will be local from UTEP or community colleges majoring in neuroscience and public health-related fields. The other 6 students will be recruited from outside El Paso, focusing on minority-serving institutions. This will increase program reach outside of the El Paso area while continuing to promote the involvement of underrepresented minorities in biomedical research. The program will also amplify outreach efforts to El Paso area high schools by including hands-on training for 3 high school teachers to incorporate low-cost neuroscience methods and SUD research knowledge into their curriculum. The program will also partner with Americans for Medical Progress (AMP) to invite local high school students to UTEP to network and learn more about science and SUD research careers. Specifically, this program aims at: 1) Continuing to increase the number of undergraduate students conducting research in neuroscience and related fields to provide information that will help reduce health disparities produced by SUDs and 2) Further increasing the number of high school teachers and students in the El Paso region with research skills and knowledge related to neuroscience and SUDs.