The Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR) program at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) has a documented track record of increasing the workforce in clinical and translational research on health disparities since 2002. Our program consists of formal didactic research training (Component I) through an established institutionally supported post -doctoral Master of Science in Clinical and Translational Research (MSc). We have already enrolled 112 health professionals from multiple disciplines, including medicine, occupational therapy, audiology, dental medicine, nursing, pharmacy and psychology, among others. During this last cycle of funding, the program supported 46 peer reviewed articles on topics relevant to health disparities such as cancer, HIV/AIDS, diabetes, infant/maternal health, and mental health. The most qualified graduates from Component I compete to receive additional support for pilot projects through Component II. Our graduates have been able to submit and obtain competitive grants from NIH such as K99/R00, R21 and SCORE awards. We also have scholars who have obtained funding from the Department of Justice and Department of Education in addition to the pilot projects awards available from other UPR programs. We will continue our successful Component I program of training scholars through our established MSc as well as our Component II program to provide advanced research skills to those scholars who excel in Component I or who have already had formal clinical and translational research training. Our renewal is innovative as it will focus on the needs identified through ongoing evaluation of the program: improving methodological knowledge and skills and addressing barriers to obtaining K awards. In addition, we will enhance our program with improvements derived from our continuous program evaluation. The main enhancements of this renewal period will be additional trainings in novel methodologies, strengthening our mentoring components, and the establishment of a K club.