# Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2024 · $4,559,316

## Abstract

ABSTRACT
 The Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) Combined
Cohort Study (CCS) is a large, comprehensive, prospective cohort study designed to investigate a spectrum of
questions relating to the basic science, clinical science, and epidemiology of HIV infection in the US, with a
focus on comorbidities among men and women living with HIV. The purpose of this application is to support
the Data Analysis and Coordination Center (DACC) for the CCS.
 The specific aims of the DACC are: 1) To optimize the contributions of the MACS and the WIHS to the
understanding of the pathogenesis and treated history of HIV infection in U.S. adults by providing
epidemiological and statistical expertise, and initiating and sustaining successful scientific partnerships, to
support the unified science agenda; 2) To coordinate the recruitment of 2,500 new MACS/WIHS-CCS
participants, including coordination of the administration of standardized baseline visits across all clinical
research sites and integration of data from new recruits with the existing combined database; 3) To coordinate
research initiatives and scientific presentations; to facilitate communication amongst CCS and external
investigators, Working Groups and committees; to orchestrate study protocol and form revision; to coordinate
outcome ascertainment and adjudication of clinical events; and to disseminate key scientific findings; 4) To
develop and maintain a web-based data management system to harmonize and integrate data from the MACS
and WIHS, as well as manage new data collected per the CCS protocol. We will continue our systems for:
tracking the storage and transfer of biological specimens at national repositories, producing annual public data
sets, and conducting training in methods that facilitate the appropriate use of study data for local research; and
5) To continue our quality assurance program in partnership with the clinical research sites that integrates
expertise in data management, study coordination, statistical methodology, and scientific disciplines.

## Key facts

- **NIH application ID:** 10831997
- **Project number:** 5U01HL146193-06
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Gypsyamber D'Souza
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $4,559,316
- **Award type:** 5
- **Project period:** 2019-04-09 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10831997

## Citation

> US National Institutes of Health, RePORTER application 10831997, Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study (5U01HL146193-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10831997. Licensed CC0.

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