CLINICAL AND HEALTH SERVICES RESEARCH CORE Abstract The Clinical and Health Services Research (CHSR) Core promotes multidisciplinary intervention research in diverse clinical settings that mitigates the impact of mental health disorders, substance use, and other HIV comorbidities and advances the uptake and efficacy of status neutral HIV care (i.e., HIV prevention and treatment services across the care continuum, regardless of one’s HIV status).. The CHSR Core will foster linkages and research collaborations that integrate clinical and social/behavioral approaches using a health equity lens, and contribute expertise in HIV comorbidities research in clinical settings. In the next five years, CHSR Core will promote innovation and build on our experiences to expand our focus to populations experiencing mobility (i.e., a consistent threat to continuity of care), and advance research and implementation of interventions and strategies that ensure accessible, equitable, and flexible status neutral HIV care. We will promote implementation research on the latest innovations (e.g., novel PrEP formulations; injectable buprenorphine for opioid use disorder) in communities most impacted by HIV, that adapts to current and emerging threats to EHE and improving health of people with HIV (PWH). Harnessing the expertise of CIRA investigators to address current global crises, we will focus efforts to generate novel insights relevant to individuals who are “in transition or who have recently resettled in new, temporary, or permanent housing,” such as those experiencing poverty and houselessness in the US and those crossing international borders voluntarily or by force. We will stimulate research with an intentional health equity lens across stages of the research process. We will foster rigorous research focused on applying and evaluating novel digital health approaches to maximize reach, evaluation, and impact of the latest biomedical advances and interventions to enhance the health of individuals with and at substantial risk for HIV. Consistent with the priorities of 2022- 2025 National HIV/AIDS Strategy, Office of AIDS Research, National Institute of Mental Health, and UNAIDS 95-95-95 targets, CHSR Core’s activities will foster high impact research responsive to the greatest threats to ending the HIV epidemic.