Washington National Primate Research Center: Abstract Overall Component This P51 renewal application is submitted to the NIH for funding for FY 61-65 for the Washington National Primate Research Center infrastructure support as one of seven Primate Research Centers within the national network of NIH-based research centers requiring infrastructure support for ongoing specialized research requiring the NHP model. This application presents an Overall Component describing the organization of the WaNPRC as it relates to the host institution, the University of Washington, as well as the reporting structure of the WaNPRC to the University of Washington’s Office of Research. The Overall Component also delineates the structure internal to Center, detailing its administrative, scientific, and animal research units. A focus is given to the long-standing Neuroscience Unit which has recently expanded, as well as the re-organization of the Infectious Disease and Translational Medicine Unit and the newly formed Gene Therapy and Regenerative Medicine Scientific Unit. A recommendation of the WaNPRC’s National Scientific Advisory Board was to consolidate its colony locations, now completed at the Arizona site, fully described within the Animal Resources Division. The Global Programs Division has continued to extend its international collaborations and ensure nonhuman primate availability benefitting the overall NPRC research network. Of special significance is the scientific progress over the last funding period in multiple biomedical specialties, including performance progress on aspects of SARS-CoV-2. The WaNPRC has undergone a transition in its reporting structure to the UW Office of Research and a thorough analysis for strategic planning purposes for the upcoming funding period. Supportive documentation in the form of Letters of Support are included as well as a detailed report of the budget figures requested aligned with justifications for associated budget requests. Governance and oversight of the WaNPRC are described as well as a narrative regarding the key organizational changes that have recently evolved at the Center. This P51 renewal grant application demonstrates the WaNPRC’s mission aligning its resources and funding as a primary underpinning of the mission of the National Institutes of Health.