Project Summary This Program brings together a multidisciplinary team from Baylor College of Medicine, MD Anderson Cancer Center, Johns Hopkins Bloomberg School of Public Health, Texas A&M University, and Rice University to examine factors influencing the progression of clonal hematopoiesis to hematologic malignancy in mice and humans. To facilitate this bold undertaking, Core B (the Administrative Core) will coordinate the activities of the Program. This Core will (1) facilitate communication within and outside the Program by organizing monthly scientific meetings including all Program participants and quarterly meetings of Program leadership. The Core will facilitate an annual meeting including all participants and internal and external advisory board members to discuss progress and generate feedback. In addition, the Core will ensure that work is communicated to the scientific community in a timely fashion through presentations, publications, and data release. (2) The Core will be responsible for sound fiscal management including budgeting and distribution of funds. (3) The Core will coordinate ongoing evaluation of the Program through internal and external advisory boards and will use the advisory feedback to adjust the Program plans as needed. (4) The Core will be responsible for ensuring compliance with ethical considerations with regard to animal and IRB protocol approvals and good laboratory practices. The Core will ensure that all participating investigators have appropriate and current ethics training. The Core will also oversee research rigor by ensuring training of all Program personnel and rigorous review. This Core will also be responsible for statistical evaluation of plans in the Projects. Overall, Core B will facilitate the highest level of productivity throughout the Program, allowing each Project and Core to work together to achieve our overall goal of understanding how modifiable stressors cause expansion and malignant transformation in patients with clonal hematopoiesis.