# Cortical Circuits Underlying Functional Recovery Following Stroke

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $366,175

## Abstract

Project Summary
Stroke is one of the leading causes of long-term disability in the United States. Recovery from
stroke-induced disability affects patients’ long-term quality of life. The goal of the proposed
project is to unravel the circuit mechanisms underlying functional recovery after stroke. We will
employ innovative approaches using state-of-the-art two-photon imaging techniques combined
with optogenetic stimulation in mice. These approaches will allow us to monitor and manipulate
the same neural circuits longitudinally. Through these novel approaches, we will test the
hypothesis that different classes of neurons have different roles in stroke recovery. Our
approach will provide the basis for identifying more effective interventions that promote stroke
recovery through cell-type-specific manipulation.

## Key facts

- **NIH application ID:** 10834167
- **Project number:** 5R01NS131549-02
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Takashi Sato
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $366,175
- **Award type:** 5
- **Project period:** 2023-05-01 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10834167

## Citation

> US National Institutes of Health, RePORTER application 10834167, Cortical Circuits Underlying Functional Recovery Following Stroke (5R01NS131549-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10834167. Licensed CC0.

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