# Core B: Biorepository and Biospecimen Resource Facility Core

> **NIH NIH P30** · DARTMOUTH COLLEGE · 2024 · $377,952

## Abstract

ABSTRACT
The basis of molecular epidemiologic research lies in the combination of biospecimens and linked subject data.
Over the past two phases of our COBRE Center for Molecular Epidemiology, we have created a unique
Biorepository and Biorespecimen Resource Facility Core with a state-of-the-art and internationally competitive
infrastructure incorporating advanced robotic and bioinformatic systems. Careful handling of biologic samples
with well-integrated de-identified specimen coding, tracking, and data systems are essential for applying
cutting-edge technologies to rapidly advance our understanding of the molecular basis of complex disease
interactions. The Core has handled over 400,000 diverse samples, created over 270,000 aliquots, and
assembled and distributed over 50,000 specimen sets to specialized laboratories. Reflecting the high value of
the Core to the insitutional research mission, the Biospecimen Resource Facility – containing over 615,000
samples – expanded into a larger, on-site, and newly renovated space with modernized security and back-up
systems for long-term biospecimen storage. An advanced laboratory information management and
biospecimen tracking system has been implemented, and our automated equipment has been upgraded for
even higher throughput sample processing with flexible configuration to assimilate future technological
advancements. The wealth of experience, optimized protocols, and efficient systems management approaches
in the Biorepository Core allow the support of a broad range of downstream analyses including novel chemical
assays, genome wide analyses, metabolomics, and metagenomics. The Core has continued to expand its
ability to accommodate diverse specimen types and applications including processing, archiving, and isolations
for single cell genomics applications. In Phase III, we will: expand our biorepository services (Aim 1); grow our
user base by creating and disseminating materials about our offerings (Aim 2); and extend and adapt our array
of services for the wider research community, while continuously evaluating our performance and repertoire of
services and developing a strategic plan to achieve long-term sustainability (Aim 3). By providing a centralized
and integrated biorepository resource, including study design consultation, we will continue to i) enable
efficient, appropriate, and safe collection and storage of biomaterials, ii) utilize quality-controlled sample
processing, archiving, and extraction procedures, iii) provide access to experienced investigators with decades
of experience in human sample storage and use, and iv) facilitate collaboration and integration across projects
and investigators. In Phase III, we will refine our marketing and financial plans for sustainability, and train
investigators on ways to expedite research translation and commercialization. Thus, we will continue this vital
and successful Core to support new initiatives seeded by the Pilot Project Program, along with...

## Key facts

- **NIH application ID:** 10834193
- **Project number:** 5P30GM149408-02
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** Brock C Christensen
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $377,952
- **Award type:** 5
- **Project period:** 2023-05-01 → 2028-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10834193

## Citation

> US National Institutes of Health, RePORTER application 10834193, Core B: Biorepository and Biospecimen Resource Facility Core (5P30GM149408-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10834193. Licensed CC0.

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