# How Brains Build Navigational Variables and Use them to Guide Behavior

> **NIH NIH R35** · ROCKEFELLER UNIVERSITY · 2024 · $575,453

## Abstract

Project Summary / Abstract
Our brain provides us with a sense of where we are in space. The importance of this sense is clear when we
become spatially disoriented, like when one is confused about one’s orientation after exiting a subway station.
Central to the understanding of how brains give rise to spatial cognition has been the discovery of place cells in
the 1970’s (i.e., neurons that are active when animals are in one location in space), head-direction cells in the
1980’s (i.e., neurons that are active when animals face one compass direction), and grid cells in the early
2000’s (i.e., neurons that are active when animals are in a grid of locations in space). A fundamental next step
in our understanding of spatial cognition would be to describe the circuit-level interactions that give rise to such
physiological activity patterns and to understand how such signals ultimately influence navigational behavior.
We wish to leverage the advanced genetic, behavioral, anatomical and physiological tools in Drosophila, to
achieve three broad goals. First, we wish to rigorously characterize neural circuits that explain how
navigational signals are built. Second, we wish to improve the tasks that flies perform while we record from
their brain, which will allow us to isolate cells and circuits required for the formation of spatial working
memories. Third, we aim to reveal molecular, cellular and circuit mechanisms by which such memories are
formed and guide behavior. This work should allow us to more rigorously link molecular factors, through their
effects on cells and circuits, to their function in spatial-cognition. Our discoveries should ultimately help to
inform how humans perform navigational tasks like driving home from work or finding a car in a parking lot,
alongside how to approach neurological conditions in which such abilities are impaired, like in Alzheimer’s
disease.

## Key facts

- **NIH application ID:** 10835100
- **Project number:** 5R35NS132252-02
- **Recipient organization:** ROCKEFELLER UNIVERSITY
- **Principal Investigator:** GABY MAIMON
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $575,453
- **Award type:** 5
- **Project period:** 2023-05-01 → 2031-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10835100

## Citation

> US National Institutes of Health, RePORTER application 10835100, How Brains Build Navigational Variables and Use them to Guide Behavior (5R35NS132252-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10835100. Licensed CC0.

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