# Harmonization and Joint Analysis of Human Brain Single-Cell Datasets

> **NIH NIH RF1** · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $344,508

## Abstract

Project Summary/Abstract
Neurodegenerative diseases like Alzheimer's, Parkinson's, and Multiple Sclerosis affect millions of people
globally. Researchers have made recent advances in studying these diseases by analyzing single cells in
postmortem brain tissues. But these diseases are complex and hard to understand. We aim to create a
comprehensive atlas of cell types and states in the human brain across the spectrum of neurodegenerative
diseases. We plan to do this by harmonizing and analyzing data with BRAIN Initiative-generated reference data
using state-of-the-art methods. By creating this atlas, we hope to identify potential targets for therapy and develop
new treatments for these debilitating diseases. This project will provide a valuable resource for the neuroscience
community by allowing a more comprehensive understanding of the cellular landscape in healthy and diseased
brains, facilitating comparisons between normal and pathological conditions.

## Key facts

- **NIH application ID:** 10835501
- **Project number:** 3RF1AG071683-01S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** VIVEK SWARUP
- **Activity code:** RF1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $344,508
- **Award type:** 3
- **Project period:** 2021-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10835501

## Citation

> US National Institutes of Health, RePORTER application 10835501, Harmonization and Joint Analysis of Human Brain Single-Cell Datasets (3RF1AG071683-01S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10835501. Licensed CC0.

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