Data Management and Biostatistics Core SUMMARY The primary objectives of the Data Management and Biostatistics Core (DMBC) are to establish a centralized data management system for both laboratory and field data from research projects within the ICEMR, provide statistical assistance and training to ICEMR consortium members, and improve biostatistical capacity for malaria research and control in Ethiopia. To achieve these objectives, the DMBC will aid investigators with tasks such as creating data dictionaries, designing data entry forms, and ensuring data quality using standard operating procedures and quality control checks. Our previous ICEMR has provided the DMBC with profound experiences in managing multi-layered data, including remote sensing data, ecological and geospatial features, population genomics data, and clinical information generated through the proposed projects. The DMBC will utilize a cloud-based data management system developed from the previous ICEMR, which will be upgraded and customized to suit the new project's requirements. Emphasis will be placed on the use of standardized terminology and electronic data capture, monitoring of data quality, establishing a comprehensive sample tracking system, enhancing data security, and facilitating data sharing in accordance with NIH guidelines. The DMBC will play a critical role in managing the different types of datasets collected by the ICEMR projects and in implementing the data management and sharing plan. The specific aims of the DMBC are: 1) establish a standardized data acquisition and management system for all ICEMR activities; 2) provide statistical support and training to ICEMR members; and 3) develop and implement scientific data sharing plan. The DMBC will be under the direction of Dr. Ming-Chieh Lee at UCI and supported by biostatisticians and data managers in both the United States and Ethiopia.