DATA MANAGEMENT CORE Abstract The Data Management Core's continuing mission is to ensure that the Southern and Central Africa ICEMR effectively and efficiently designs, conducts, analyzes, and reports field and laboratory studies with data that can be integrated and combined across sites and studies and shared with local and global partners through the Nchelenge Learning Lab, ClinEpiDB, and databases for genomic data. To this end, we established an effective and efficient collaborative environment with an infrastructure for and culture of reproducible research. These successes are enabled by staff with statistical, database, and information technology (IT) expertise, empowered by an IT infrastructure based on Research Electronic Data Capture (REDCap), the REDCap mobile application for mobile data collection, and Open Data Kit (ODK) software that meets our goals while being attuned to field realities. As part of the Southern Africa ICEMR, we conduct weekly data management meetings with personnel from all projects and cores, serving as a forum for multi-disciplinary discussion of data, statistical, and IT issues. We will continue to conduct these weekly meetings in this ICEMR renewal with the goal of shifting data management responsibilities and expertise to data management personnel at Macha Research Trust and the Tropical Diseases Research Centre so these institutions have full capability by the end of the ICEMR program.