SUMMARY – CORE A The Administrative Core A is requested to facilitate internal interactions among PIs of Projects 1-2, leaders of the four technology components, Core B (Antibody Neutralization), and the IAVI Biobank at both on- and off- campus sites as well as with the NIAID. Core A is responsible for the overall organization, management and decision making. Core A will provide progress reports to NIAID. Data sharing, acquisition/protection of intellectual property and involvement of institutional resources are within its purview. This Core will organize communications, group meetings, teleconferences, presentations and publication of data with rigorous statistical oversight. Timely submission to NIAID of all abstracts, manuscripts and reviews supported by the P01 will be through this Core. The allocation of resources to meet various program goals, fiscal prioritization, responsibilities for resource sharing and information and reagent transmission is an important responsibility. This Core will also manage a budget for program-related travel and will support a Scientific Advisory Board (SAB) to evaluate scientific progress and consider pre-clinical efforts moving toward future clinical development considerations. Core A will oversee the annual SAB meeting in Boston, coordinating travel and other logistics involving NIAID program staff, SAB and co-investigators attending the meeting. It will organize an educational component including a seminar series related to structural and molecular approaches to immunogen design, vaccine delivery in general and RNA vaccines in particular to be co-hosted by Drs. Reinherz and Weissman. Relevance Core A provides overall administrative support, scientific management, and fiscal oversight for the Program. Additionally, Core A coordinates and fosters interactions among the investigators, collaborators and external advisors to facilitate the most productive and impactful outcome among the proposed studies.