# Neutralizing Antibody Core

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2024 · $300,463

## Abstract

SUMMARY – CORE B
Neutralizing Antibody Core
Recent insights into HIV-1 Env structure and function are yielding a variety of new approaches aimed at
designing more advanced and novel immunogens for eliciting broadly neutralizing antibodies (bnAbs) through
vaccination. As improved immunogens enter detailed pre-clinical and clinical studies, it has become critical that
the in vitro assays used for making measurements of vaccine-elicited antibody responses have the ability to
distinguish incremental advances in magnitude, breadth, and durability. Core B (Neutralizing Antibody Core)
will provide standardized and validated GCLP-compliant neutralizing antibody assay services to assist
in the development and evaluation of novel mRNA-based immunogens advanced by this P01 program
and comparison of vaccine-elicited mAbs with existing and newly defined patient-derived bnAbs. These
services will provide critical data that will help guide immunogen design and strategies for vaccine formulation
and delivery proposed in Project 1 and Project 2. To accomplish these goals, we propose the following three
Specific Aims:
Specific Aim 1: Assess vaccine-elicited neutralizing antibody responses in wildtype and KI mice immunized
 with novel mRNA-based chimeric HIV-1 MPER-TM immunogens.
Specific Aim 2: Screen patient serum samples from HIV-1 infection cohorts to identify individuals with
 MPER-specific neutralizing activity for mAb cloning.
Specific Aim 3: Characterize the breadth and potency of neutralizing activity and ADCC for novel mAbs
 cloned from vaccinated animals and HIV-1 infected patients.

## Key facts

- **NIH application ID:** 10837609
- **Project number:** 1P01AI181597-01
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** Michael Scott Seaman
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $300,463
- **Award type:** 1
- **Project period:** 2024-04-01 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10837609

## Citation

> US National Institutes of Health, RePORTER application 10837609, Neutralizing Antibody Core (1P01AI181597-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10837609. Licensed CC0.

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