# Biomarker Core

> **NIH NIH P30** · STANFORD UNIVERSITY · 2024 · $368,403

## Abstract

1. SUMMARY (Biomarker Core)
Biomarkers have enormous value for the detection, management, and treatment of disease, but also for the
development of novel therapeutics. The utility of biomarkers is most evident in the management of
cardiovascular disease and diabetes, but biomarkers, especially predictive, easily obtainable ones, are still
largely absent with respect to neurodegenerative diseases. The best fluid biomarkers currently available for
Alzheimer’s disease (AD) include; Aβ, tau, and neurofilament in CSF, a biofluid which is difficult to collect in
healthy, at-risk populations or on a repeated basis. Other biomarkers for AD include imaging modalities which
are often very expensive or have low sensitivity and specificity at the individual level. The members of this core
have considerable experience in unbiased multi-omic screens and data analysis and, over the years, have
published numerous studies towards developing new biomarkers for neurodegenerative and other diseases.
Enabled by the current ADRC, the core leaders and collaborators have used biospecimens from Stanford
ADRC participants and generated extensive preliminary data with unbiased deep immune phenotyping,
proteomics, and transcriptomics of human CSF resident cells, and discovered novel Parkinson's disease (PD)
biomarkers. Based on this expertise, the mission of this Biomarker Core is to facilitate the discovery of novel
biomarkers for AD and PD, as well as new biology underlying the pathological processes that lead to dementia
in line with the core mission of the NAPA. This will be achieved by pursuing the collection of genetic and
molecular measurements from a broad source of tissues from ADRC participants; the processing and
dissemination of this information in useable formats through web portals and other means (i.e., “Deep
Phenotyping Database”); the analysis and bioinformatics integration of the collected information with clinical
and imaging data, as well as information from public databases; and the development and dissemination of
new data analysis algorithms and pipelines.

## Key facts

- **NIH application ID:** 10837698
- **Project number:** 5P30AG066515-05
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** TONY WYSS-CORAY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $368,403
- **Award type:** 5
- **Project period:** 2020-06-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10837698

## Citation

> US National Institutes of Health, RePORTER application 10837698, Biomarker Core (5P30AG066515-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10837698. Licensed CC0.

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