The overarching goal for Administrative Core A will be to facilitate the research activities of this Program Project, thereby enabling Program members to focus on scientific progress. This Core will (1) Assume responsibility for Program oversight to ensure that all work carried out meets requirements established by the National Cancer Institute and the National Institutes of Health, (2) Provide financial oversight to the Principle Investigator, Project Leaders, and Core Directors, (3) Organize and coordinate meetings among Project Leaders, Core Directors, and their associated laboratories, (4) Facilitate and coordinate effective communication between Project Leaders and the External Advisory Board, and (5) Organize Program Project-related travel and facilitate submission of manuscripts. The personnel responsible for Core A include Dr. Roger Greenberg (Principal Investigator and Project 1 Leader), and Mrs. Laura Murillo, Director of Administration for the Penn Center for Genome Integrity (PCGI). In addition to her support for Dr. Greenberg and this Core, Mrs. Murillo will assist all Project and Core Leaders across this P01 with the daily management of all scientific aspects (research meetings, seminars, manuscript, and progress report preparations) and resources (budget allocation, expense reports, and Core usage monitoring) for all projects and cores. As the Principal Investigator and Core A Director, Dr. Greenberg will take primary responsibility of this Core’s functions, which includes providing direction for Mrs. Murillo. In this role, Dr. Greenberg will meet frequently with the Project and Core leaders to jointly discuss the overall direction of the research. Mrs. Murillo will serve as coordinator in scheduling these meetings and will also meet weekly (or more frequently as needed) with Dr. Greenberg.