PROJECT SUMMARY / ABSTRACT Trichomonas vaginalis (TV) is the most prevalent non-viral sexually transmitted infection (STI) globally. For reasons unknown, unlike other STIs, TV prevalence follows a bimodal population age distribution. Infection increases risk of preterm birth, infertility, and cervical neoplasia and is associated with a striking health disparity, with women of African descent disproportionately affected. TV infection increases the risk of HIV transmission and acquisition. Despite the high prevalence and