# Neuropathology Core

> **NIH NIH P30** · YALE UNIVERSITY · 2024 · $474,647

## Abstract

SUMMARY – Yale ADRC Neuropathology Core
The neuropathological assessment of brains provides a critical resource and asset for disease-oriented
neuroscience by connecting clinical, biomarker-based, genetic and neuroimaging observations to pathogenic
tissue-based changes. Alzheimer’s Disease (AD) research was enhanced by thorough neuropathological studies
uncovering closely inter-related histopathological features with other defined neurodegenerative diseases and/or
co-morbidities such as cerebrovascular disease and hippocampal sclerosis. Precise postmortem diagnosis is
therefore critical for validating candidate antemortem biomarkers and imaging characteristics. The Yale ADRC
Neuropathology Core has been designed to enhance research within the Yale ADRC and to promote tissue-
based Alzheimer Disease research throughout the neurodegenerative disease research community. The
biobanking of AD brains will be supplemented by the parallel collection of skin or dura derived fibroblasts from
deceased individuals, which will be reprogrammed to induced pluripotent stem cells (IPSC). This approach leads
to uniquely paired samples that allow the directed investigation of neurodegenerative disease processes in
frozen/fixed brain samples while also providing a cell culture model of the same individual. Further, Yale is home
to a large aged rhesus colony due to decades of pre-eminence of non-human primate (NHP) neuroscience. The
incorporation of NHP brains the for assessment of age-related neurodegeneration in rhesus macaque will allow
correlation of AD pathology and imaging across species, and it will provide high quality tissue samples for high
resolution ultrastructure due to due to a well-controlled, minimal postmortem interval. The Neuropathology Core
will also closely interact with other Cores of the Yale ADRC.
The overarching goal of this application is to develop and establish a highly contemporary biobank, which merges
traditional biobanking approaches with advancements in stem cell technology for the analysis of Alzheimer’s
Disease, and also offers access to well-studied aged NHP brain tissue. Successful completion of these goals
will have a major impact on the overall success of the Yale ADRC.

## Key facts

- **NIH application ID:** 10839783
- **Project number:** 5P30AG066508-05
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Anita Juliane Huttner
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $474,647
- **Award type:** 5
- **Project period:** 2020-06-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10839783

## Citation

> US National Institutes of Health, RePORTER application 10839783, Neuropathology Core (5P30AG066508-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10839783. Licensed CC0.

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