CORE A – PROJECT SUMMARY Core A is the Administrative center of the entire Program. Core A will provide the essential administrative support for all of the investigators in each project and core. This includes fiscal management and oversight for all components of the Program Project; timely reporting of results and milestone reports, organization and communication of all Program Project meetings and activities, including internal and external advisory meetings, programmatic seminars, and outreach. Core A also provides Biostatistics support for each project and core, data analysis and hypothesis testing, biological pathways and network analysis of omics data. The overall goal of this Core is to facilitate the seamless interaction of projects and cores, communicate scientific and technological findings, and harmonize interpretation and communication of complex data sets between program members. The Core A administrative component will ensure compliance with all regulatory and governmental guidelines, fiscal management, provide scientific leadership, effective communication to all members and advisors, and an administrative support structure to ensure the coordination of all Program Project activities.