Project Abstract Summary Youth violence is a critical public health concern. In 2019, there were 46.9 homicides per 100,000 for youth ages 10 to 24 in the Kansas City (KC) metro area compared to 7.82 in the U.S. overall. Youth homicide is the third leading cause of death for individuals 15 to 24 years nationally (National Center for Injury Prevention, 2021), and the leading cause of death for youth in this age group in the KC metro area. Youth violence disproportionately affects racial and ethnic youth. Black and Hispanic/Latinx youth experience greater disparities in youth violence nationally and in the Kansas City (KC) metro area. In 2019, 71% of the 57 youth homicides in the KC metro area involved Black or Hispanic/Latinx youth ages 10 to 24. The goal of the proposed KC Youth Violence Prevention Center is to examine implementation of ThrYve (Together Helping Reduce Youth Violence) as a multicomponent approach to prevent youth violence (i.e., youth homicides) and reduce associated risks (e.g., intentional injury hospital admission), particularly among Black and Latinx youth. The geographic focus is the KC metro area, including both KC, KS & KC, MO neighborhoods with high rates of youth violence. The ThrYve model examines the implementation of two prevention strategies including: (a) ThrYve4Change, a youth mobilization strategy and (b) REVIVE, a scaled multisite hospital violence prevention program. The rationale is that testing the ThrYve model using a more rigorous approach across multiple neighborhoods (i.e., school catchment areas) with elevated rates of youth violence and high hospitalization rates will expand the evidence base for the effectiveness and generalizability of participatory strategies to prevent and reduce youth violence. The study will use interrupted time series and multiple baseline designs across three neighborhoods (i.e., school catchment areas) in the KC metro area. Additionally, a multisite hospital violence prevention program will be evaluated across four local hospital sites. The following aims will be examined in the study to understand the impact of the comprehensive prevention strategies on community outcomes and related factors: Specific Aim 1: Evaluate the effectiveness of the multi-component ThrYve Model, including ThrYve4Change (youth mobilization strategy) & REVIVE (Reducing the Effects of Violence through Intervention and Victim Empowerment) (multisite hospital violence prevention program) on changes in community conditions (i.e., prevention practices, programs, & policies) and youth homicide rates. Specific Aim 2: Examine the impact of the ThrYve4Change youth mobilization strategy on associated risks & protective factors (e.g., academic performance) for youth in three neighborhoods (i.e., school catchment areas). Specific Aim 3: Evaluate the effectiveness of implementing a scaled hospital violence prevention program on firearm-related hospital admissions and readmissions of youth participants.