# Resource Core III: Biological Impacts Core

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $430,469

## Abstract

PROJECT SUMMARY / ABSTRACT
The mission of “Resource Core III: Biological Impacts Core” is to provide state-of-the-art biochemical and
molecular pathology tools to the research projects supported by the Correction of Neurological Disease via Allele
Specific Excision of Pathogenic Repeats (CASEPR) program. Complementing the work of Cores I and II, the Bio
Impacts Core III will play an integral role in assessing the molecular phenotype of animal models following in
vivo genome editing. The Core will develop innovative new assays to evaluate the impact of targeted CRISPR-
mediated excision of pathogenic alleles on the transcriptome and proteome of neurons, glia, and resident-
immune cells in the mammalian brain and circulatory system. Research support services include nucleic acid
and protein isolation, quantitative PCR and western blot, automated microscopy, post-image analysis and
quantification, immunological assays, and data management. All samples will be tracked and stored using a
laboratory management system, and results disseminated back to the research project leads. Research output
from Core III will provide essential data on both the efficacy and safety of the genome editing approaches; and
the suite of services will accelerate the timeline from preclinical studies to IND by consolidation of resources and
expertise.

## Key facts

- **NIH application ID:** 10840855
- **Project number:** 5U19NS132303-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** JENNIFER A DOUDNA
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $430,469
- **Award type:** 5
- **Project period:** 2023-05-15 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10840855

## Citation

> US National Institutes of Health, RePORTER application 10840855, Resource Core III: Biological Impacts Core (5U19NS132303-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10840855. Licensed CC0.

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