The Diabetes Research Center at the University of Washington is part of the national program supported by NIDDK and acts as the focal point and umbrella for diabetes research in the Greater Seattle area. Its mission is to enhance research, education and training in diabetes, obesity, and related disorders and to promote an environment of collaborative research in these conditions by (1) Providing support to affiliate investigators through its four biomedical research cores; (2) Conducting a pilot and feasibility program that provides grant support for new investigators in diabetes research and to established investigators in other disciplines; (3) Sponsoring an interactive enrichment program comprising symposia, named lectures, retreats and workshops to inform the community of the latest developments in the area; (4) Ensuring the development of young investigators by providing postdoctoral and graduate student fellowships for salary support and training in its biomedical research cores; and (5) Developing new research methods and technologies based on the evolving needs of its investigators. To accomplish this goal, the Center is organized around four biomedical research cores (Cellular and Molecular Imaging Core, CRISPR, Vector and Transgenic Mouse Core, Metabolic and Cellular Phenotyping Core, and Proteomics and Bioinformatics Core) and an Administrative Core that also manages the Pilot and Feasibility (P&F) and Enrichment Programs. Along with the commitment of the University of Washington and other Seattle institutions of research space and additional financial support, the Diabetes Research Center is a dynamic and constantly evolving center that supports 116 Seattle-based affiliate investigators who receive annual funding in excess of $135.9 million in overall direct costs (more than $116.2 million of which is from NIH and $24.5 million from NIDDK). These investigators are making important scientific contributions in the areas of (1) Pathophysiology, prevention and treatment of type 2 diabetes; (2) Central regulation of body weight and glucose metabolism; (3) Complications of diabetes; (4) Etiology, pathogenesis and treatment of type 1 diabetes; and (5) Clinical trials and large-scale epidemiologic studies.