# Renewal: Strategies and Methods for Complex Molecule Synthesis

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $664,356

## Abstract

Project Summary/Abstract
The goal of this program is to develop new strategies and methods for the synthesis of
biologically active secondary metabolites (natural products). A significant portion of
our efforts will be dedicated to identifying efficient preparations of these complex
molecules. These compounds and their unique derivatives will serve as novel small
molecules to combat a range of indications associated with cancer as well as
inflammation and pain. Our synthetic studies will lead to new applications of C–H, C–C
and C–N bond functionalization methodology in organic synthesis as well as advancing
the concept of skeletal editing and its application to the preparation of topologically
complex molecules. Finally, working with collaborators, we will gain unique entry into
the use of natural products and their derivatives to perturb biological function and
ultimately provide promising starting points for new therapeutics.

## Key facts

- **NIH application ID:** 10840931
- **Project number:** 5R35GM130345-07
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Richmond Sarpong
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $664,356
- **Award type:** 5
- **Project period:** 2019-01-01 → 2027-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10840931

## Citation

> US National Institutes of Health, RePORTER application 10840931, Renewal: Strategies and Methods for Complex Molecule Synthesis (5R35GM130345-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10840931. Licensed CC0.

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