# Host and parasite factors influencing P. vivax RBC invasion and asexual development

> **NIH NIH R01** · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $691,533

## Abstract

Abstract
Plasmodium vivax threatens half of the world’s population and is surprisingly resilient to on-going malaria
elimination efforts, partially due to its unique characteristics and our poor understanding of its biology. Here, we
propose to conduct state-of-the-art transcriptomic analyses using materials derived directly from Cambodian
patients to rigorously assess the importance of red blood cell polymorphisms, host immunity and parasite factors
in modulating the efficacy of red blood cell invasion and P. vivax intraerythrocytic development. Our studies will
not only provide a better understanding of the fundamental molecular and cellular processes underlying blood
stage P. vivax infections but will also provide a solid foundation to develop better malaria vaccines against this
important but understudied human pathogen.

## Key facts

- **NIH application ID:** 10840968
- **Project number:** 5R01AI165483-03
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** David Serre
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $691,533
- **Award type:** 5
- **Project period:** 2022-06-08 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10840968

## Citation

> US National Institutes of Health, RePORTER application 10840968, Host and parasite factors influencing P. vivax RBC invasion and asexual development (5R01AI165483-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10840968. Licensed CC0.

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