# Injectable drug-delivery system to repair the blood-brain-barrier after ischemic stroke

> **NIH NIH K00** · STANFORD UNIVERSITY · 2024 · $88,407

## Abstract

PROJECT ABSTRACT
Appropriate functioning of the nervous system is tremendously important to our quality of life. The nerves
within our body branch from the spinal column and can extend up to one meter away. Peripheral nerve injuries
are a common occurrence and can readily heal in most cases. However, end-organs beyond ~18 inches away
from the nerve body, are highly susceptible to poor reinnervation outcomes and long-term detriments. A main
reason for this being the slow growth rate of the axons (1-2mm/day or 1 inch/month). Some tissues, such as
skeletal muscle, can remain ready for reinnervation for 18-24 months. However, current intervention strategies
are limited, and most injuries are left to resolve naturally. This application aims to develop a strategy capable of
promoting quicker neurite outgrowth and preserving the muscle in a healthy state until reinnervation can occur.
This application focuses on tissue-nanotransfection mediated delivery of non-viral gene cargo to induce
molecular changes and to reprogram cells. The ability to deliver cargos locally to the site of injury opens
avenues beyond nerve injury for gene and cell-based therapeutics with a precision medicine approach.
Completion of the F99 phase sets a strong intellectual, technical and professional foundation for the
postdoctoral (K00) phase of this award. During the K00 phase, training in understanding how cell and gene-
based therapies impact neurodevelopmental and neurodegenerative conditions will develop knowledge,
expertise, and skills essential to becoming an independent investigator.

## Key facts

- **NIH application ID:** 10840976
- **Project number:** 5K00NS124174-04
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Jordan Taylor Moore
- **Activity code:** K00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $88,407
- **Award type:** 5
- **Project period:** 2021-09-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10840976

## Citation

> US National Institutes of Health, RePORTER application 10840976, Injectable drug-delivery system to repair the blood-brain-barrier after ischemic stroke (5K00NS124174-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10840976. Licensed CC0.

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