Administrative Core – Summary The Administrative Core (Admin Core) for this program, “Preventing Infant Infection with Implementation Science in Malawi” (PRI3SM), will play a central role in achieving our overall objective to identify successful implementation strategies to eliminate MTCT (EMTCT) in Malawi and beyond. The Admin Core will oversee the operation, coordination, management, and evaluation of the three projects focused on the EMTCT cascade. We will join in crosscutting support with the implementation science core and data science and analytical core to provide advanced support and coordination to each of these study projects. The Admin Core will support the activities of the projects and cores to enhance the potential for cross protocol comparisons through harmonized instruments, data systems, and procedures. The Admin Core will also support Ministry of Health program evaluations and provide mechanisms for engagement of young investigators through existing capacity building programs. Through the existing infrastructure of UNC Project Malawi, the Admin Core will assist all core and project directors with operational and budgetary oversight and management, including submission of progress reports, communication between EMTCT clinical, research, policy and implementing partners and communication with NICHD. The core will organize activities that enhance collaborations between both senior and junior investigators based at UNC-CH, UNC Project Malawi, the Malawi Ministry of Health and PEPFAR implementing partners. These synergistic and mature relationships have been developed over the past twenty years of EMTCT activities in Malawi beginning with a collaboration with the Malawi MOH and the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) to implement HIVNET012 regimen in 2002; the establishment of DAIDS network clinical trials including the IMPAACT network; numerous single site research activities through CDC (the BAN study) and NICHD funding; and an increasing number of implementation science trials0. Most importantly, policy and practice changes have led to well-established relationships with the Malawi Ministry of Health and implementing partners. The Admin Core will also assemble and facilitate meetings of both an External and Internal Advisory Board, and coordinate participation in annual local and global EMTCT meetings. The Admin Core will ensure that overall goals for the program are accomplished as outlined below. Aim 1. Enhance the program effort by optimizing communication, decision-making and sharing among the research project teams, the support cores and the implementing partners. Aim 2. Develop and maintain shared, dedicated administrative infrastructure to ensure timely and accurate monitoring, reporting, and regulatory compliance of all EMTCT activities. Aim 3. Provide administrative support to strengthen existing partnerships in Malawi, between UNC Project, Malawi Ministry of Health, PEPFAR implementing partners and communi...