PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE The CRISPR Vision Program is a truly team science unique effort to advance gene editing therapeutic candidates for several retinal channelopathies towards the clinic. This proposal leverages synergy between discoveries in engineering and biology and requires close collaborations and contacts between academic labs, industry partners, regulatory professionals, manufacturing facilities, the National Institutes of Health (NIH), and the U.S. Food and Drug Administration (FDA). This large effort therefore requires strong administrative support from the Administrative (Admin) Core, whose overarching goal is to ensure efficiency, teamwork, and synergy among the Projects and Cores by providing infrastructure spanning software, meetings, finances, staffing, logistics, communications, and publications. All these activities are critical to an innovative team science approach taken by the CRISPR Vision Program. The Admin Core builds on organizational principles that have proven successful during Phase I of the SCGE and several extramural projects since 2018. These principles include several supporting functions including communication, record keeping, process reports, publications, infrastructure, working relationships with university admin, software tools, and many more. In practice, four primary tasks will be executed. First, the Admin Core will assign and manage personnel to ensure all Projects and Cores are appropriately staffed and form committees to oversee all duties. The Admin Core will perform project management tasks based on the information they collect from regular meetings, comparison of progress to the phase timelines, and other factors. Second, the Admin Core will support communication and synergy among team members through organizing regular meetings, adopting standard practices for data and protocol sharing, and providing software tools to assist with project management and team communication. Third, the Admin Core will coordinate external communications of research, datasets, protocols, and processes including information sharing with the NIH, the SCGE Consortium Translational Coordination and Dissemination Center, and across other Centers, and dissemination and publication of results and resources. Finally, the Admin Core will provide financial management, interface with institutional administration, and ensure the cost-effective use of resources across the Projects and Cores. Overall, the Admin Core will help integrate the Projects so that true Team Science can be achieved within each Project and also between Projects. The points of synergy are expected to provide a rapid translation of promising genome editing technology into the clinic. The Admin Core will be led by Dr. Krishanu Saha, who brings leadership experience with many large team science initiatives including the Phase I of the SCGE. The Core will benefit from a Program Manager who will execute the tasks above with Dr. Saha and an ex...