# mTORC1 Regulation by Upstream Stimuli

> **NIH NIH R35** · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $492,000

## Abstract

ABSTRACT
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr kinase that senses multiple
upstream stimuli to regulate cell growth, metabolism, and autophagy. mTOR is the catalytic component of a
multi-protein complex called mTOR complex 1 (mTORC1). Elevated mTORC1 activation is common in multiple
human disease including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. Small molecules
like rapamycin that target and inhibit mTORC1 are used in the clinic with limited success. Thus, deciphering the
molecular mechanisms by which mTORC1 is regulated is crucial to treat mTORC1-mediated disease. The
overall objective of this proposal is to decipher the molecular mechanisms by which mTORC1 is regulated by
upstream stimuli. Specifically, this proposal is focused on mTORC1 regulation by amino acids and G-protein
coupled receptors (GPCRs). We anticipate that the studies in this proposal will yield new insights into mTORC1
regulation by upstream stimuli and will uncover novel therapeutic targets to perturb mTORC1-mediated disease.

## Key facts

- **NIH application ID:** 10842368
- **Project number:** 5R35GM149351-02
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Jenna L Jewell
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $492,000
- **Award type:** 5
- **Project period:** 2023-06-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10842368

## Citation

> US National Institutes of Health, RePORTER application 10842368, mTORC1 Regulation by Upstream Stimuli (5R35GM149351-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10842368. Licensed CC0.

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