SUMMARY ADMINISTRATIVE CORE Collaborative science faces unique challenges that parallel the size and scope of the project or Program. Beyond increased scientific challenges (such as data integration and harmonization), so too do the challenges to coordinate, communicate, and collaborate effectively within the Program increase. The proposed project includes four major research projects, supported by three resource cores, executed by a diverse multi-disciplinary team distributed across five research institutions. The goal of this Administrative (Admin) Core is to facilitate their coordination, communication, and collaboration. Our leadership team has extensive experience coordinating and managing large, multi-investigator programs; most notably as a small animal testing center in Somatic Cell Genome Editing (SCGE) Phase I funding, and as a precision genetics center (JAX Center for Precision Genetics, JCPG) improving animal models of human disease and move them towards translation to the clinic. In each of these programs, we have established frameworks for organizing our teams, sharing information across projects and institutions, tracking progress and milestones, and communicating progress to key stakeholders as well as the NIH program officers. Our previous experience leading Administration/Coordination Cores for multi- institutional, NIH-funded Programs makes us uniquely qualified to develop and execute on the administrative goals of this U19. The Admin Core will provide managerial and administrative structure for this U19 Program through the following Aims. In Aim 1 we establish an effective administrative governance structure to assure success of this U19 Program. We use prior experience and Program-specific characteristics to build a clear hierarchy of governance and include guidance from clinical experts in neurodegenerative diseases to hasten IND application. In Aim 2 we develop a formal meeting schedule to foster the communication needed to execute on the goals of this proposal. The Admin Core will be responsible for managing this schedule, recording, and reporting out on the progress and action items identified in these meetings. The Admin Core will use these reports to monitor progress toward milestones of the Program and each Project for Aim 3, assisting NIH Program officials in their alignment of our Program with SCGE Phase II. Finally, the Admin Core will communicate the findings from this U19 Program with the Translational Coordination and Dissemination Center for external distribution and assist in the creation of a shared learning and training education hub.