# Transition Metal-Catalyzed Alkene Functionalization

> **NIH NIH R35** · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $305,031

## Abstract

Project Summary
After carbon and hydrogen; oxygen, nitrogen, and fluorine are the three most common elements found in
pharmaceuticals and drug candidates. Lead identification and optimization is typically the longest part of the drug
discovery process, taking about five out of the average fifteen years, to bring a drug to market. This is partially
due to the requirement to synthesize and test of a large number of potential drug candidates through structure
activity relationship (SAR) studies. As such, the development of new organic methodologies for the rapid
synthesis of organic molecules is of utmost importance to synthetic chemists. The research described herein
focuses on the development of novel approaches for the synthesis of C–N, C–O, C–S, C–P, C–F, C–Cl, C–Br,
and C–B bonds, in a selective and expedient manner. Moreover, it seeks to allow for divergent synthesis; where
from a single common intermediate libraries of potential pharmaceuticals could be synthesized in a single
synthetic transformation simply by varying the reagents. More specifically, the proposal focuses on the
development of an array of carbon-carbon double bond difunctionalization of using a copper or palladium
catalyst.

## Key facts

- **NIH application ID:** 10842932
- **Project number:** 2R35GM125029-06
- **Recipient organization:** UNIVERSITY OF TEXAS AT AUSTIN
- **Principal Investigator:** Kami Lee Hull
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $305,031
- **Award type:** 2
- **Project period:** 2017-08-01 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10842932

## Citation

> US National Institutes of Health, RePORTER application 10842932, Transition Metal-Catalyzed Alkene Functionalization (2R35GM125029-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10842932. Licensed CC0.

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