PROJECT SUMMARY/ABSTRACT RTI International proposes to serve as the Coordinating Center (CC) for the Centers for Disease Control and Prevention (CDC)-funded research network of study sites to assess barriers and facilitators for enrollment and sustained participation in the National Diabetes Prevention Program (NDPP) and Medicare DPP (MDPP) and to determine the long-term effectiveness and cost-effectiveness of the programs. As the CC for this opportunity, RTI will facilitate collaboration to achieve the program objectives by providing scientific and statistical expertise, as well as offer logistical and data management support. As the CC, RTI will contribute to the design, development, and management of a centralized protocol with common core data elements and establish study operations to efficiently monitor progress. RTI will also collect, manage, analyze, report, and disseminate the research findings. Specifically, we propose to enhance network efficiency and productivity by providing logistical and operational support, scientific expertise, and consensus building; ensure adherence to standardized study protocols by developing and sustaining a central database of harmonized data; and determine the long-term effectiveness of the NDPP/MDPP by providing analytical and statistical support to the sites and by conducting cross-site analyses. RTI has over 35 years of experience as a CC for clinical research networks, providing scientific expertise and administrative and operational support. In addition, we will draw on our extensive experience collecting and analyzing data as part of researching, evaluating, and supporting implementation of the NDPP and MDPP programs that we will draw on in execution of this CC opportunity. Our team will be headed by Dr. Sara Jacobs, an established principal investigator of the National Institutes of Health–funded Sickle Cell Disease Implementation Consortium Data CC, who also is an experienced researcher and evaluator of the NDPP/MDPP, having led projects for both CDC and the Centers for Medicare & Medicaid Services. In addition, the RTI team offers six experts: Dr. Thomas Hoerger (economist and NDPP/MDPP expert), Dr. Jennifer Popovic (electronic health record clinical data extraction), Benjamin Allaire (claims data and control group construction), Dr. Jamie Humphrey (social determinants of health), Karen Strazza (qualitative data), and Whitney Battestilli (database construction). Together, this team brings the expertise to support and guide all aspects of the NDPP/MDPP research network.