Abstract Cancer Center Administration The City of Hope Comprehensive Cancer Center (COHCCC) Administration provides effective and efficient administrative support to facilitate COHCCC strategic and operational priorities. During the current funding cycle, Administration was re-organized to strategically enhance its support of COHCCC priorities and address review critiques. A now fully integrated and realigned Administration is led by an experienced Associate Director for Administration (ADA), Ms. Ashley Baker Lee. Administration has expanded and now includes four additional senior managers to better facilitate the basic, clinical, translational, and population-based research and education mission of the COHCCC. Through this integration and expansion, the role that Administration now plays has grown considerably to ensure COHCCC and Cancer Center Support Grant (CCSG) needs are represented, prioritized, and aligned in an effective manner Administration facilitates COHCCC strategic priorities, oversees all COHCCC programmatic activities, and promotes collaborative multidisciplinary and transdisciplinary translational research by integrating basic, translational, population-based, and clinical research as well as training activities across the COHCCC. Administration is also responsible for coordinating all COHCCC research administrative and strategic functions in pursuit of COHCCC’s mission. Administration ensures COHCCC adherence to all CCSG expectations and guidelines from proposal stage through reporting. Administration supports key COHCCC functions such as space management, Shared Resources business support, financial management, faculty recruitment/retention, meeting/seminar facilitation, pilot program management, membership activities, connections to central offices, communications, and strategic planning/evaluation support. Evidence of impact of Administration includes successful recruitment and onboarding of 48 new COHCCC Program Members; development and endorsement of a new COHCCC strategic plan; expansion of laboratory research space through purchase/renovation of a 141,000 sq. ft. building; and implementation of multiple IT systems in support of research, including Epic and OnCore.