SUMMARY The Administrative Core coordinates all activities for the Core Center for Musculoskeletal Biology and Medicine (CCMBM) so as to comply with all regulatory requirements, enhance research productivity, facilitate efficient adoption and use of state-of-the-art technologies and computational approaches, expand the research field, promote collaborative research, and develop innovative projects and investigators. The goals of the Administrative Core are to: 1) provide strong scientific leadership for a broad, diverse, and sustainable CCMBM community, 2) provide administrative management, fiscal oversight, and evaluation and reporting of all CCMBM activities, 3) coordinate and integrate CCMBM activities and communications to serve MSK investigators, and 4) manage the Enrichment Program to maximize the impact of CCMBM resources on MSK research. The services provided by the Administrative Core are grouped into 7 general categories, including leadership, fiscal management, membership activities, reporting, communications, Enrichment Program activities, and Enrichment Program funding. The Administrative Core will be led by a Director (Alliston) and Associate Director (Nissenson), who are assisted by a Center Operations Team, the Internal Executive Committee, and the CCMBM Advisory Board. The Administrative Core leverages the abundant and outstanding resources at UCSF and in the University of California to accomplish these goals, creating synergies that benefit musculoskeletal investigators and the scientific community more broadly. The ability of CCMBM to deliver high quality professional core services in an innovative, responsive, and cost-effective manner benefits immensely from the UCSF Research Resource Program, which organizes systems for the management of Core services and finances and training for Core staff. We also plan to build on the developed UCSF-based CCMBM foundation to expand, integrate, and support a sustainable, diverse community of MSK investigators throughout the University of California system. As such, the activities of the Administrative Core not only support the CCMBM but are the cornerstone for the integrated musculoskeletal ecosystem at UCSF, and increasingly at a regional level.