# Epidemiology, Bioinformatics, and Study Design (EBSD) Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $167,852

## Abstract

SUMMARY
As musculoskeletal research advances and state-of-the-art tools evolve, investigators face new demands for
data management and analysis, and they seek resources for translating preclinical discovery to humans. The
Epidemiology, Bioinformatics, and Study Design (EBSD) Core will address those demands, thereby
enhancing research productivity. It will do this by providing unique epidemiologic resources that encourage
collaborations between basic, translational, and clinical researchers. The Core will guide researchers, make
critical connections, and support use of analytic and other consultative resources, in part through the creation of
crucial educational tools. The Core will thus ensure the rigor and reproducibility of the research conducted.
The EBSD Core will build on its achievements to date, maintaining successful programs while adding new,
innovative initiatives such as stimulating cross-cutting research on the genetics and genomics of musculoskeletal
traits. First, the core will facilitate access to and use of large osteoporosis and osteoarthritis longitudinal
databases from multicenter observational studies and randomized trials coordinated by UCSF, including rich
associated biological and imaging resources (Aim 1). With these resources, the EBSD Core will enable
researchers to test hypotheses about pathogenesis, risk factors, and the course of bone and joint disease.
Proposed expanded offerings will particularly encourage translational discovery, with data and tools for genetic
and genomic analyses of musculoskeletal traits, research on aging and muscle, and cutting-edge research using
artificial intelligence or new technologies. Second, the EBSD Core will provide individualized consultative
services to musculoskeletal researchers, as it has done for over 120 projects and proposals in the current P30
award period (Aim 2). Core directors and faculty will advise researchers through one-on-one consultations
(directly or leveraging other existing UCSF resources), through EBSD-run work-in-progress groups, and through
the embedding of an EBSD Core faculty member within a clinical department. A novel pathway for consultative
guidance will help investigators navigate resources—particularly existing UCSF bioinformatics resources, for
which demand is increasing precipitously. Third, the EBSD Core aims to educate the musculoskeletal research
community (Aim 3). The core will create an online musculoskeletal-focused wayfinding and educational tool to
equip researchers, across all research methodologies, who have diverse analytical needs ranging from spatial
proteomics to image segmentation algorithms. The core will also leverage existing UCSF educational resources,
providing guidance about formal course offerings and continuing medical education. In accomplishing these
aims, the EBSD Core will serve musculoskeletal researchers across the bench-to-bedside continuum, enhancing
productivity and stimulating collaborations to facilitate translationa...

## Key facts

- **NIH application ID:** 10843659
- **Project number:** 2P30AR075055-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Anne Louise Schafer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $167,852
- **Award type:** 2
- **Project period:** 2019-07-15 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10843659

## Citation

> US National Institutes of Health, RePORTER application 10843659, Epidemiology, Bioinformatics, and Study Design (EBSD) Core (2P30AR075055-06). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10843659. Licensed CC0.

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