# Administrative Core

> **NIH NIH U19** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $1,261,856

## Abstract

ABSTRACT Administrative Core
The mission of the Multicenter Osteoarthritis (MOST) study is to conduct, facilitate, and promote high impact
research on the etiology and prevention of osteoarthritis (OA) and its consequences of pain and loss of function.
During the proposed 4th cycle of MOST (MOST4), we plan to accomplish this goal through the acquisition,
management, analysis and sharing of data on OA, risk factors and functional consequences of disease. The
primary goal of the MOST4 Administrative Core is to ensure that processes are in place and functioning to
support the accomplishment of this mission. The Administrative Core will manage finances, and the following
interactions: 1) internally among the study units (the Cores (Clinical Data Collection and Management, Analysis,
Imaging) and Projects); 2) with external researchers; 3) between institutions involved in the MOST study
including Boston University; University of Alabama, Birmingham; University of California, San Francisco;
University of Iowa; the funding agency (NIA); reading centers; and specialized laboratories.The Administrative
Core will be under the leadership of Core co-Leaders Drs. David Felson and Tuhina Neogi, supported by an
Executive Committee consisting of the other Cores' leaders. The overall team of MOST4 investigators include a
mix of senior experienced NIH-funded faculty and junior faculty establishing their careers with a focus on studies
of OA, pain and disability. The first cycle of the MOST study (MOST1) was funded in 2001, and investigators
affiliated with this cohort have a long history of collaboration, having published over 180 papers reporting
important findings related to OA epidemiology and risk factors, pain, function, and other outcomes. Among the
unique features of the study has been the multidisciplinarity of its investigators and research. A range of topics
have been studied, including MRI findings in the knee, pain sensitization, biomechanical data such as the ground
reaction force, measurement of muscle function, studies of crystal deposition, assessment of physical activity,
among others. The current proposal for the 4th cycle of MOST (MOST4) represents an expansion of this
multidisciplinary focus. The goals of the Administrative Core are to provide leadership to successfully manage
the overall study's execution; plan, direct and integrate all MOST study activities; provide transparent
communication across projects and cores; and foster cross-project collaboration. We will accomplish these goals
through providing leadership and administrative oversight for the following Specific Aims: Scientific &
Operational Management, including single Institutional Review Board processes; Financial Management; Study
Output Management & Dissemination; Pilot Grant Program; Community Advisory Board Engagement;
Communications & External Collaboration. Through these activities, the Administrative Core will ensure the
successful operations of MOST4 under the strong and c...

## Key facts

- **NIH application ID:** 10843721
- **Project number:** 5U19AG076471-02
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** DAVID Tobin FELSON
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,261,856
- **Award type:** 5
- **Project period:** 2023-06-01 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10843721

## Citation

> US National Institutes of Health, RePORTER application 10843721, Administrative Core (5U19AG076471-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10843721. Licensed CC0.

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