Increasingly, advances in skin biology and disease research depend on cross-disciplinary, collaborative approaches. The broad, long-term objective of the UC Irvine Skin Biology and Disease Resource-based Center is to promote cross-fertilization between multiple disciplines that allows an innovative, integrated approach to regulatory mechanisms in skin biology and disease. This will be achieved through resource cores in Multiomics, Imaging & Engineering, and Systems Biology. The interactions between investigators and cores, and between cores, will be coordinated through the Administrative Core, which will also be responsible for an enrichment program that promotes goals of the Center. The Center has been highly successful in the first cycle, leading to increased funding for skin research and innovative research reflected in strong and increased productivity of outstanding publications. In addition, our existing Cores have successfully innovated and created new tools and technologies for skin research. The Specific Aims in the coming cycle are to: 1. Maintain Cores in Multiomics, Imaging & Engineering, and Systems Biology that foster interdisciplinary, collaborative skin science. 2. Promote a team science approach to skin research. 3. Promote translational skin research. 4. Recruit and support junior investigators researching biology and diseases of the skin. 5. Produce and make available resources useful to the skin research community at large. The Center will continue to have strong impact on the well-funded, innovative research community, leading to significant discoveries relevant to regulatory mechanisms in skin biology. The Center will also draw investigators from other fields into NIAMS-funded research and promote entry of junior investigators into skin biology and disease research.