Systems Biology refers to the integration into biology of ideas and methodologies from mathematics, engineering, computer science, physics, and chemistry, with the goal of deriving greater understanding from data—especially data that are complex, dynamic and/or high-dimensional. Systems biology makes frequent use of explicit, quantitative models, and concerns itself both with how useful models can be derived from data and how models can be used to generate hypotheses and drive the collection of new data. Biomedical research is becoming increasingly reliant on systems biology approaches, yet researchers face many challenges in acquiring the skills and insights to take full advantage of them. The goal of the Systems Biology Core is to enable skin biology researchers to incorporate Systems Biology in their research, improving productivity, enhancing rigor and reproducibility, and increasing research impact. This will be achieved by providing services directed toward education, research assistance, and research integration. Strategies include retreats, workshops, clinics, research development meetings, and project-specific consultation and collaboration. Novel strategies include short-term embedding of “Skin Systems Biology Fellows” within the laboratories of skin researchers, and proactive participation of core scientists in the re-analysis and integration of data generated by the skin research community. Core activities will leverage the expertise and resources of systems biology faculty with expertise in modeling and data analysis; long-standing experience in teaching interdisciplinary science; and a track-record of collaboration with skin biologists during the first grant period. It also leverages the infrastructure of a large campus-wide center devoted to systems biology, the Center for Complex Biological Systems. Within the context of the P30 center, the Systems Biology Core will act as a hub connecting the data-gathering effort of the Multiomics and Imaging/Engineering Cores to new hypothesis generation and improved experimental design in all areas of skin research.