Abstract: This proposal meets a critical need to strengthen the foundations of basic science by developing a program to train students in biochemistry and molecular biology. UNMC has outstanding translational research in cancer, neuroscience and other clinically relevant foci, all of which rely heavily on training in foundational biochemistry and molecular biology. Despite this, we do not yet have a training program designed to bolster this crucial fundamental area of research. The overall goal of our proposal is to enhance training in basic biochemistry and molecular biology through the funding of 9 predoctoral students, 3 of which will come from internal UNMC support. The program will rely on a carefully vetted list of experienced and motivated mentors, as well as new mentors who will work in tandem with more experienced mentors. The program will select highly qualified and diverse predoctoral students and provide them with outstanding training in scientific rigor, critical thinking, and the bench skills necessary to succeed in academic or biomedical industry research. Training will not be limited to research skills, but will provide exposure to a wide range of careers, and to develop the requisite skills in professionalism, leadership, organization, time management, teaching, oral presentations, scientific writing, etc. The proposed training program includes formal didactic courses, including a key discussion-based course in critical thinking in biochemistry and molecular biology directed by the PI of this proposal, as well as journal clubs, seminars, oral and poster presentations and other opportunities for scientific discourse. The program is designed for students to complete their training within a 5-year window and to produce an outstanding cadre of graduates that will contribute significantly to the Nebraskan and US scientific workforce.