# Administrative Core

> **NIH NIH U19** · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2024 · $208,181

## Abstract

Project Summary Adm Core
The overall goal of our Autoimmunity Center of Excellence (ACE) renewal proposal is to
investigate the altered states of B cells and macrophages that contribute to the
pathogenesis of SLE. Three individual projects will examine basic questions related to
the role of immune cell states that are induced during periods of disease activity. The
Principal Project will study the differences in B cell states between patients with active
SLE, patients in long-term remission, and healthy individuals to determine which
programs are associated with disease activity. The Pilot Project will determine the
mechanisms by which age associated B cells acquire antigen presentation functions
that amplify T cell activation. The Collaborative Project will study the activation of
myeloid cells that infiltrate SLE kidneys and determine whether their presence in blood
or urine precedes flare. All three projects will share samples from the same patient
cohorts that include legacy ACE cohorts, a cohort of patients in long-term remission and
a newly acquired prospective cohort of patients at high risk of disease flare. The
Administrative Core will be central to the functioning of our ACE by providing
budgetary and financial oversight, by managing interactions with the clinical
investigators who will be recruiting patients for the proposed translational studies, by
providing biostatistical oversight and by providing logistical support to facilitate scientific
interactions within the Feinstein ACE, with collaborators and with other ACE members.
The Core will continue to be co-directed by Drs Anne Davidson and Betty Diamond who
have vast experience with collaborative studies and will have complementary roles in
managing interactions with collaborators. In addition, the Administrative Core will be
supported by an established clinical infrastructure that includes a large patient pool,
well-established patient cohorts, expert clinical collaborators, IRB approved protocols
for data and blood collection, an established mechanism to obtain samples from
patients at home or work, an experienced biostatistics collaborator and appropriate
scientific technology. The close existing relationships between all the investigators and
collaborators and with our long-time administrative staff should ensure smooth
functioning of the Core and successful implementation of all projects.

## Key facts

- **NIH application ID:** 10844194
- **Project number:** 2U19AI144306-06
- **Recipient organization:** FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Betty Diamond
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $208,181
- **Award type:** 2
- **Project period:** 2019-05-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10844194

## Citation

> US National Institutes of Health, RePORTER application 10844194, Administrative Core (2U19AI144306-06). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10844194. Licensed CC0.

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