# Principal Project-Characterization of ANA+ and ANA-B cells in individuals with SLE and healthy subjects

> **NIH NIH U19** · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2024 · $251,183

## Abstract

Little is known about the differences between B cells reactive with nuclear antigen
(ANA+) and ANA- B cells in individuals with systemic lupus erythematosus (SLE) or
whether the regulation of ANA+ and ANA- B cells differs between SLE patients and
healthy individuals. We will study activation and transcriptional profile in ANA+ and
ANA- naïve, unswitched memory and switched memory B cells in individuals with active
SLE, individuals with SLE in remission and healthy individuals. We will determine the
antigenic and BCR repertoire of ANA+ B cells in these three cohorts to understand B
cell selection. These studies are designed to reveal if there are aspects of ANA+ B cells
in SLE that makes them susceptible to a therapeutic intervention that will not affect
those B cells engaged in a protective response.

## Key facts

- **NIH application ID:** 10844198
- **Project number:** 2U19AI144306-06
- **Recipient organization:** FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Betty Diamond
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $251,183
- **Award type:** 2
- **Project period:** 2019-05-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10844198

## Citation

> US National Institutes of Health, RePORTER application 10844198, Principal Project-Characterization of ANA+ and ANA-B cells in individuals with SLE and healthy subjects (2U19AI144306-06). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10844198. Licensed CC0.

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