# Animal Modeling Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $253,587

## Abstract

PROJECT SUMMARY
The Animal Modeling Core (AMC) of the University of Michigan Skin Biology and Diseases Resource-based
Center (UM-SBDRC) serves as a critical shared resource that facilitates the design, development, and
characterization of mouse models aimed at gaining deeper insight into skin biology and disease, significantly
advancing the overall goals of our Center and the NIAMS mission. Genetically-engineered mouse models
(GEMMs) provide a powerful tool for testing hypotheses that emerge from the sophisticated sequencing and
gene editing studies driven by the Functional Analytics Core (FAC), extending them to the physiologically
relevant setting of an intact organism. Although many GEMMs are available, new project-specific models are
frequently needed. However, there are major impediments to successful new mouse model development and
characterization, including the significant time investment and cost needed to acquire detailed empirical
knowledge and expertise to be consistently successful. In addition, commercial GEMM development is frequently
suboptimal and costly. The continued long-term goal of the AMC is to override these and other obstacles for
Center Members by offering comprehensive GEMM services for skin-related studies through the following aims:
1) provide hands-on support for the design and development of new GEMMs and proper use of existing mouse
models; 2) provide training for consistent and reproducible in vivo GEMM manipulation; and 3) provide detailed
instruction and assistance for conducting comprehensive GEMM phenotyping. The work performed with AMC
support during the current grant period has greatly benefitted Center Members by advancing their skin-relevant
research leading to impactful publications, collaborations, and grants. Given the complex interplay of multiple
cell types that is best studied in an intact organism, rigorous mouse modeling remains critically important as a
powerful tool for understanding the pathogenesis of skin disease and as an engine for producing pre-clinical
disease models that should ultimately lead to much-needed new therapies.

## Key facts

- **NIH application ID:** 10844251
- **Project number:** 2P30AR075043-06
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** ANDRZEJ A. DLUGOSZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $253,587
- **Award type:** 2
- **Project period:** 2024-08-15 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10844251

## Citation

> US National Institutes of Health, RePORTER application 10844251, Animal Modeling Core (2P30AR075043-06). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10844251. Licensed CC0.

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