# Medical Genetics Research Fellowship Program

> **NIH NIH T32** · BAYLOR COLLEGE OF MEDICINE · 2024 · $670,335

## Abstract

PROJECT SUMMARY
 This is an application for continued support for years 46-50 of a postdoctoral training program in
medical genetics based in the Department of Molecular and Human Genetics (DMHG) at Baylor College of
Medicine (BCM). The DMHG is a bridging department with major clinical activities and strong programs in
basic, translational, and clinical research. It uniquely integrates many of the activities that are traditionally
found dispersed through many academic departments and centers at most US academic institutions into a
single department at BCM. At our core, the training mission unifies all three domains and the success of this
training program over the past five decades reflects that integration. The emphasis of this postdoctoral
program is on medical and human genetics and on molecular approaches. There are 90 training faculty, 67
with primary and 23 with secondary appointments in the DMHG (compared with 90 at the last competing
renewal submitted in 2017). Our strategic plan has enhanced the training environment including new faculty
recruitment, development of new clinical training tracks, formation of a diagnostic laboratory joint venture,
development of a virtual platform to facilitate patient engagement in clinical care, education, and research, and
establishment of an Office of Community Engagement and Diversity (OCED). However, the core of the DMHG
mission remains research spanning all areas of human and model organism genetics with focus on medical
genetic practice. Trainees derive mainly from ACGME accredited residency and fellowship programs. The
focus of the program is to attract highly qualified ABMGG MD, MD/PhD, and PhD trainees who seek an
intensive research experience. In the past four years of this cycle of funding, 82% of 12 month slots were
assigned to such trainees. Powerful drivers of training include faculty integration within the DMHG Division of
Research affairs including multiple NIH funded centers, clinical implementation of innovative technologies in
the genetic diagnostic arena, and integration of these elements into clinical training. Our stellar alumni who
now populate our and many other medical genetics programs is evidence of the success of this integrated
approach. Major strengths of the training environment include a large clinical genetics component; large,
comprehensive, and sophisticated diagnostic laboratories; high national ranking of NIH funding and awards
among US genetics departments (1st for over decade); NIH Large Scale Sequencing Center; NIH Intellectual
and Developmental Disability Research Center; NIH Center for Mendelian Genomics now GREGoR; NIH
Undiagnosed Diseases Network (UDN) Clinical Site (CS), Sequencing Core (SC), and Model Organism
Screening Center (MOSC); NIH Knockout Mouse Phenotyping Program (KOMP3), NIH CLINGEN, and NIH
Center for Precision Medicine Modeling (CPMM).

## Key facts

- **NIH application ID:** 10844351
- **Project number:** 5T32GM007526-47
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Brendan Lee
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $670,335
- **Award type:** 5
- **Project period:** 1978-09-30 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10844351

## Citation

> US National Institutes of Health, RePORTER application 10844351, Medical Genetics Research Fellowship Program (5T32GM007526-47). Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/grant/nih/10844351. Licensed CC0.

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